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Literature summary extracted from

  • Maddock, K.R.; Huff-Lonergan, E.; Rowe, L.J.; Lonergan, S.M.
    Effect of pH and ionic strength on mu- and m-calpain inhibition by calpastatin (2005), J. Anim. Sci., 83, 1370-1376.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpastatin inhibition of mu-calpain is higher at 295 mM NaCl than at 165 mM. Inhibition is not altered by pH from pH 6.0-7.5 Sus scrofa
3.4.22.52 NaCl mu-calpain is more active at 165 mM NaCl than at 295 mM NaCl Sus scrofa
3.4.22.53 calpastatin inhibition of m-calpain is greater at pH 7.5 than at pH 6.5 at both 165 mM and 295 mM NaCl. Percentage inhibition is greater at 295 mM than at 165 mM NaCl Sus scrofa
3.4.22.53 NaCl m-calpain is more active at 165 mM NaCl than at 295 mM NaCl Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Sus scrofa
-
-
-
3.4.22.53 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 skeletal muscle
-
 Sus scrofa
-
3.4.22.53 skeletal muscle
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa ?
-
 ?
3.4.22.53 succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
 Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.52 mu-calpain
-
 Sus scrofa
3.4.22.53 m-calpain
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.52 6.5
-
 mü-calpain Sus scrofa
3.4.22.53 6.5 7.5 activity of m-calpain is greater at pH 7.5 than at pH 6.5 Sus scrofa